PEPTIDES IN LIPID BILAYERS - STRUCTURAL AND THERMODYNAMIC BASIS FOR PARTITIONING AND FOLDING

被引：171

作者：

WHITE, SH

WIMLEY, WC

机构：

[1] Department of Physiology and Biophysics, College of Medicine, University of California, Irvine

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 1994年 / 4卷 / 01期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/S0959-440X(94)90063-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The lipid bilayer is commonly, but incorrectly, viewed as a slab of bulk hydrocarbon liquid bounded by thin polar regions. Recent experimental and theoretical advances reveal the true complexities of the bilayer and its interactions with peptides. These are reviewed in the context of five fundamental questions that must be addressed in order to arrive at a structural and thermodynamic framework that is useful for studies of a broad array of biological processes.

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页码：79 / 86

页数：8

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