THE AMYLOID PRECURSOR PROTEIN IS CONCENTRATED IN NEURONAL LYSOSOMES IN NORMAL AND ALZHEIMER-DISEASE SUBJECTS

被引:150
作者
BENOWITZ, LI
RODRIGUEZ, W
PASKEVICH, P
MUFSON, EJ
SCHENK, D
NEVE, RL
机构
[1] HARVARD UNIV,SCH MED,DEPT PSYCHIAT,BOSTON,MA 02115
[2] HARVARD UNIV,SCH MED,DEPT PEDIAT,BOSTON,MA 02115
[3] HARVARD UNIV,SCH MED,PROGRAM NEUROSCI,BOSTON,MA 02115
[4] ATHENA NEUROSCI,PALO ALTO,CA
[5] INST BIOGERONTOL RES,SUN CITY,AZ
[6] CHILDRENS HOSP MED CTR,BOSTON,MA 02115
关键词
D O I
10.1016/0014-4886(89)90156-8
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
引用
收藏
页码:237 / 250
页数:14
相关论文
共 30 条
[1]   IMMUNOCHEMICAL IDENTIFICATION OF THE SERINE PROTEASE INHIBITOR ALPHA-1-ANTICHYMOTRYPSIN IN THE BRAIN AMYLOID DEPOSITS OF ALZHEIMERS-DISEASE [J].
ABRAHAM, CR ;
SELKOE, DJ ;
POTTER, H .
CELL, 1988, 52 (04) :487-501
[2]   IMMUNOHISTOCHEMICAL EVIDENCE FOR THE DERIVATION OF A PEPTIDE LIGAND FROM THE AMYLOID BETA-PROTEIN PRECURSOR OF ALZHEIMER-DISEASE [J].
ALLSOP, D ;
WONG, CW ;
IKEDA, S ;
LANDON, M ;
KIDD, M ;
GLENNER, GG .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (08) :2790-2794
[3]   LOCALIZATION OF AMYLOID BETA-PROTEIN MESSENGER-RNA IN BRAINS FROM PATIENTS WITH ALZHEIMERS-DISEASE [J].
BAHMANYAR, S ;
HIGGINS, GA ;
GOLDGABER, D ;
LEWIS, DA ;
MORRISON, JH ;
WILSON, MC ;
SHANKAR, SK ;
GAJDUSEK, DC .
SCIENCE, 1987, 237 (4810) :77-80
[4]   IMMUNOCYTOCHEMICAL LOCALIZATION OF THE PRECURSOR PROTEIN FOR BETA-AMYLOID IN THE RAT CENTRAL NERVOUS-SYSTEM [J].
CARD, JP ;
MEADE, RP ;
DAVIS, LG .
NEURON, 1988, 1 (09) :835-846
[5]  
CATALDO A M, 1987, Society for Neuroscience Abstracts, V13, P1150
[6]  
GLENNER G, 1983, BRANBURY REPORT, V15, P137
[7]   ALZHEIMERS-DISEASE - INITIAL REPORT OF THE PURIFICATION AND CHARACTERIZATION OF A NOVEL CEREBROVASCULAR AMYLOID PROTEIN [J].
GLENNER, GG ;
WONG, CW .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1984, 120 (03) :885-890
[8]   ALZHEIMERS-DISEASE AND DOWNS-SYNDROME - SHARING OF A UNIQUE CEREBROVASCULAR AMYLOID FIBRIL PROTEIN [J].
GLENNER, GG ;
WONG, CW .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1984, 122 (03) :1131-1135
[9]  
GLENNER GG, 1983, ARCH PATHOL LAB MED, V107, P281
[10]   CHARACTERIZATION AND CHROMOSOMAL LOCALIZATION OF A CDNA-ENCODING BRAIN AMYLOID OF ALZHEIMERS-DISEASE [J].
GOLDGABER, D ;
LERMAN, MI ;
MCBRIDE, OW ;
SAFFIOTTI, U ;
GAJDUSEK, DC .
SCIENCE, 1987, 235 (4791) :877-880