PRESYNAPTIC DOPAMINE FUNCTION IN STRIATUM OF NEUROLEPTIC-NAIVE SCHIZOPHRENIC-PATIENTS

被引：258

作者：

HIETALA, J

SYVALAHTI, E

VUORIO, K

RAKKOLAINEN, V

BERGMAN, J

HAAPARANTA, M

SOLIN, O

KUOPPAMAKI, M

KIRVELA, O

RUOTSALAINEN, U

SALOKANGAS, RKR

机构：

[1] TURKU MED CYCLOTRON PET PROJECT,TURKU,FINLAND

[2] TURKU CITY PSYCHIAT HOSP,TURKU,FINLAND

[3] ABO AKAD UNIV,ACCELERATOR LAB,TURKU,FINLAND

[4] TURKU UNIV HOSP,DEPT ANAESTHESIOL,SF-20520 TURKU,FINLAND

[5] TURKU UNIV HOSP,DEPT PSYCHIAT,SF-20520 TURKU,FINLAND

来源：

LANCET | 1995年 / 346卷 / 8983期

关键词：

D O I：

10.1016/S0140-6736(95)91801-9

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Presynaptic dopamine function (6-[F-18]-fluorodopa uptake) in the brains of seven neuroleptic-naive first-admission schizophrenic patients and eight healthy controls was studied with positron emission tomography. The fluorodopa influx constant (K-i) in putamen was higher in the patients than in controls (average mean: 0.0149 vs 0.0129, p=0.034). The changes in caudate were smaller but significantly lateralised to the left caudate. There was one catatonic schizophrenic patient in our sample. This patient had lower striatal K-i than any control. Alterations in striatal presynaptic dopamine function may constitute a part of disrupted neural circuits that predispose to schizophrenic psychosis.

引用

页码：1130 / 1131

页数：2

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