RENIN INHIBITORS - STATINE-CONTAINING TETRAPEPTIDES WITH VARIED HYDROPHOBIC CARBOXY TERMINI

被引：15

作者：

BOCK, MG ^{[1
]}

DIPARDO, RM ^{[1
]}

EVANS, BE ^{[1
]}

RITTLE, KE ^{[1
]}

BOGER, J ^{[1
]}

POE, M ^{[1
]}

LAMONT, BI ^{[1
]}

LYNCH, RJ ^{[1
]}

ULM, EH ^{[1
]}

VLASUK, GP ^{[1
]}

GREENLEE, WJ ^{[1
]}

VEBER, DF ^{[1
]}

机构：

[1] MERCK SHARP & DOHME RES LABS, RAHWAY, NJ 07065 USA

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1987年 / 30卷 / 10期

关键词：

D O I：

10.1021/jm00393a029

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：1853 / 1857

页数：5

共 26 条

[1] NOVEL RENIN INHIBITORS - SYNTHESIS OF AMINOSTATINE AND COMPARISON WITH STATINE-CONTAINING ANALOGS [J].

ARROWSMITH, RJ ;

CARTER, K ;

DANN, JG ;

DAVIES, DE ;

HARRIS, CJ ;

MORTON, JA ;

LISTER, P ;

ROBINSON, JA ;

WILLIAMS, DJ .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1986, (10) :755-757

[2] DIPEPTIDE ANALOGS - SYNTHESIS OF A POTENT RENIN INHIBITOR [J].

BOCK, MG ;

DIPARDO, RM ;

EVANS, BE ;

RITTLE, KE ;

BOGER, JS ;

FREIDINGER, RM ;

VEBER, DF .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1985, (03) :109-110

[3]

BOGER J, 1985, REGUL PEPTIDES, P8

[4] NOVEL RENIN INHIBITORS CONTAINING THE AMINO-ACID STATINE [J].

BOGER, J ;

LOHR, NS ;

ULM, EH ;

POE, M ;

BLAINE, EH ;

FANELLI, GM ;

LIN, TY ;

PAYNE, LS ;

SCHORN, TW ;

LAMONT, BI ;

VASSIL, TC ;

STABILITO, II ;

VEBER, DF ;

RICH, DH ;

BOPARI, AS .

NATURE, 1983, 303 (5912) :81-84

[5] RENIN INHIBITORS - SYNTHESES OF SUBNANOMOLAR, COMPETITIVE, TRANSITION-STATE ANALOG INHIBITORS CONTAINING A NOVEL ANALOG OF STATINE [J].

BOGER, J ;

PAYNE, LS ;

PERLOW, DS ;

LOHR, NS ;

POE, M ;

BLAINE, EH ;

ULM, EH ;

SCHORN, TW ;

LAMONT, BI ;

LIN, TY ;

KAWAI, M ;

RICH, DH ;

VEBER, DF .

JOURNAL OF MEDICINAL CHEMISTRY, 1985, 28 (12) :1779-1790

[6]

BOGER J, 1983, PEPTIDES STRUCTURE F, P569

[7]

CUMIN F, 1985, J BIOL CHEM, V260, P9154

[8] THE DETERMINATION OF ENZYME INHIBITOR CONSTANTS [J].

DIXON, M .

BIOCHEMICAL JOURNAL, 1953, 55 (01) :170-171

[9]

ERICKSON BW, 1976, PROTEINS, V2, P257

[10] A UNIQUELY POTENT RENIN INHIBITOR AND ITS UNANTICIPATED PLASMA-BINDING COMPONENT [J].

EVANS, BE ;

RITTLE, KE ;

BOCK, MG ;

BENNETT, CD ;

DIPARDO, RM ;

BOGER, J ;

POE, M ;

ULM, EH ;

LAMONT, BI ;

BLAINE, EH ;

FANELLI, GM ;

STABILITO, II ;

VEBER, DF .

JOURNAL OF MEDICINAL CHEMISTRY, 1985, 28 (12) :1755-1756

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