CLONING AND EXPRESSION OF INTERCELLULAR-ADHESION MOLECULE-3 REVEALS STRONG HOMOLOGY TO OTHER IMMUNOGLOBULIN FAMILY COUNTER-RECEPTORS FOR LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1

被引：107

作者：

DEFOUGEROLLES, AR

KLICKSTEIN, LB

SPRINGER, TA

机构：

[1] CTR BLOOD RES, 200 LONGWOOD AVE, BOSTON, MA 02115 USA

[2] HARVARD UNIV, SCH MED, DEPT PATHOL, COMM IMMUNOL, BOSTON, MA 02115 USA

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 1993年 / 177卷 / 04期

关键词：

D O I：

10.1084/jem.177.4.1187

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Based on protein sequence, we have isolated a cDNA for intercellular adhesion molecule 3 (ICAM-3), the most recently defined counter-receptor for lymphocyte function-associated antigen 1 (LFA-1). Expression of the cDNA yields a product that reacts with monoclonal antibody to ICAM-3 and functions as a ligand for LFA-1. The deduced 518-amino acid sequence of the predicted mature. protein defines a highly glycosylated type I integral membrane protein with five immunoglobulin (Ig)-like domains. The five Ig-like domains of ICAM-3 are highly homologous with those of human ICAM-1 (52% identity) and human ICAM-2 (37% identity).

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页码：1187 / 1192

页数：6

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