CLASSIFICATION OF OPIOIDS ON THE BASIS OF CHANGE IN SEIZURE THRESHOLD IN RATS

被引：175

作者：

COWAN, A

GELLER, EB

ADLER, MW

机构：

[1] Department of Pharmacology, Temple University School of Medicine, Philadelphia

来源：

SCIENCE | 1979年 / 206卷 / 4417期

关键词：

D O I：

10.1126/science.504986

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Twenty opioids have been subdivided into four classes by using flurothyl-induced seizures in rats to measure dose-response relationships, stereospecificity, naloxone sensitivity, and tolerance-cross-tolerance. The data support current theories of multiple opiate receptor types. Since the receptors involved mediate effects that are antagonized, enhanced, or unaffected by naloxone, the model is uniquely suitable for detecting novel narcotic antagonists that can then be used to differentiate opiate receptors in other systems. Copyright © 1979 AAAS.

引用

页码：465 / 467

页数：3

共 31 条

[1]

ADLER MW, 1976, J PHARMACOL EXP THER, V198, P655

[2]

ADLER MW, 1975, CURRENT DEV PSYCHOPH, V2, P31

[3]

BRIMBLECOMBE RW, 1978, GASTROENTEROLOGY, V74, P339

[4] CENTRAL AND PERIPHERAL MONOAMINERGIC MEMBRANE-PUMP BLOCKADE BY SOME ADDICTIVE ANALGESICS AND ANTIHISTAMINES [J].