EXPRESSION OF AMYLOID BETA-PROTEIN PRECURSOR MESSENGER-RNAS IN FAMILIAL ALZHEIMERS-DISEASE

被引：14

作者：

HARRISON, PJ

BARTON, AJL

PEARSON, RCA

机构：

[1] UNIV SHEFFIELD,DEPT BIOMED SCI,SHEFFIELD S10 2TN,S YORKSHIRE,ENGLAND

[2] ST MARYS HOSP,SCH MED,DEPT ANAT,LONDON,ENGLAND

[3] ST MARYS HOSP,SCH MED,DEPT PSYCHIAT,LONDON,ENGLAND

来源：

NEUROREPORT | 1991年 / 2卷 / 03期

基金：

英国惠康基金;

关键词：

INSITU HYBRIDIZATION HISTOCHEMISTRY; AMYLOID; DEMENTIA; MESSENGER RNA; GENE EXPRESSION;

D O I：

10.1097/00001756-199103000-00011

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

THE amyloid beta-protein precursor (APP) gene and its products are implicated in the pathogenesis of Alzheimer's disease. The differential expression of APP transcripts may contribute to this process. In the present study, the distribution of mRNAs encoding APP variants has been determined in the brain of three cases of familial Alzheimer's disease (FAD) using in-situ hybridization histochemistry. One FAD case was associated with a mutation in the APP gene. No differences in distribution or quantity of APP transcripts were observed between FAD cases and controls. Overexpression of APP mRNAs is therefore an unlikely explanation for the deposition of the beta-amyloid (beta/A4) peptide in FAD brains.

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页码：152 / 154

页数：3

相关论文

共 19 条

[1] INSITU HYBRIDIZATION OF NUCLEUS BASALIS NEURONS SHOWS INCREASED BETA-AMYLOID MESSENGER-RNA IN ALZHEIMER-DISEASE [J].

COHEN, ML ;

GOLDE, TE ;

USIAK, MF ;

YOUNKIN, LH ;

YOUNKIN, SG .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (04) :1227-1231

[2] AMYLOIDOSIS OF THE NERVOUS-SYSTEM [J].

GLENNER, GG ;

MURPHY, MA .

JOURNAL OF THE NEUROLOGICAL SCIENCES, 1989, 94 (1-3) :1-28

[3] SEGREGATION OF A MISSENSE MUTATION IN THE AMYLOID PRECURSOR PROTEIN GENE WITH FAMILIAL ALZHEIMERS-DISEASE [J].

GOATE, A ;

CHARTIERHARLIN, MC ;

MULLAN, M ;

BROWN, J ;

CRAWFORD, F ;

FIDANI, L ;

GIUFFRA, L ;

HAYNES, A ;

IRVING, N ;

JAMES, L ;

MANT, R ;

NEWTON, P ;

ROOKE, K ;

ROQUES, P ;

TALBOT, C ;

PERICAKVANCE, M ;

ROSES, A ;

WILLIAMSON, R ;

ROSSOR, M ;

OWEN, M ;

HARDY, J .

NATURE, 1991, 349 (6311) :704-706

[4] EXPRESSION OF BETA-AMYLOID PROTEIN-PRECURSOR MESSENGER-RNAS - RECOGNITION OF A NOVEL ALTERNATIVELY SPLICED FORM AND QUANTITATION IN ALZHEIMERS-DISEASE USING PCR [J].

GOLDE, TE ;

ESTUS, S ;

USIAK, M ;

YOUNKIN, LH ;

YOUNKIN, SG .

NEURON, 1990, 4 (02) :253-267

[5] INSITU HYBRIDIZATION HISTOCHEMISTRY AND THE STUDY OF GENE-EXPRESSION IN THE HUMAN BRAIN [J].

HARRISON, PJ ;

PEARSON, RCA .

PROGRESS IN NEUROBIOLOGY, 1990, 34 (04) :271-312

[6] INCREASED MUSCARINIC RECEPTOR MESSENGER-RNA IN ALZHEIMERS-DISEASE TEMPORAL CORTEX DEMONSTRATED BY INSITU HYBRIDIZATION HISTOCHEMISTRY [J].

HARRISON, PJ ;

BARTON, AJL ;

NAJLERAHIM, A ;

MCDONALD, B ;

PEARSON, RCA .

MOLECULAR BRAIN RESEARCH, 1991, 9 (1-2) :15-21

[7]

HARRISON PJ, IN PRESS MOL BRAIN R

[8] DIFFERENTIAL REGULATION OF AMYLOID-BETA-PROTEIN MESSENGER-RNA EXPRESSION WITHIN HIPPOCAMPAL NEURONAL SUBPOPULATIONS IN ALZHEIMER-DISEASE [J].

HIGGINS, GA ;

LEWIS, DA ;

BAHMANYAR, S ;

GOLDGABER, D ;

YOUNG, WG ;

WILSON, MC .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (04) :1297-1301

[9] RELATION OF NEURONAL APP-751/APP-695 MESSENGER-RNA RATIO AND NEURITIC PLAQUE DENSITY IN ALZHEIMERS-DISEASE [J].

JOHNSON, SA ;

MCNEILL, T ;

CORDELL, B ;

FINCH, CE .

SCIENCE, 1990, 248 (4957) :854-857

[10] SELECTIVE REDUCTION OF MESSENGER-RNA FOR THE BETA-AMYLOID PRECURSOR PROTEIN THAT LACKS A KUNITZ-TYPE PROTEASE INHIBITOR MOTIF IN CORTEX FROM ALZHEIMER BRAINS [J].

JOHNSON, SA ;

PASINETTI, GM ;

MAY, PC ;

PONTE, PA ;

CORDELL, B ;

FINCH, CE .

EXPERIMENTAL NEUROLOGY, 1988, 102 (02) :264-268