LIGHT REGULATES EXPRESSION OF A FOS-RELATED PROTEIN IN RAT SUPRACHIASMATIC NUCLEI

被引：307

作者：

ARONIN, N

SAGAR, SM

SHARP, FR

SCHWARTZ, WJ

机构：

[1] UNIV MASSACHUSETTS, SCH MED, DEPT NEUROL, 55 LAKE AVE N, WORCESTER, MA 01605 USA

[2] UNIV MASSACHUSETTS, SCH MED, DEPT MED, WORCESTER, MA 01605 USA

[3] UNIV MASSACHUSETTS, SCH MED, DEPT PHYSIOL, WORCESTER, MA 01605 USA

[4] UNIV CALIF SAN FRANCISCO, SCH MED, DEPT NEUROL, SAN FRANCISCO, CA 94143 USA

[5] UNIV CALIF SAN FRANCISCO, SCH MED, DEPT PHYSIOL, SAN FRANCISCO, CA 94143 USA

[6] VET ADM MED CTR, SAN FRANCISCO, CA 94121 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1990年 / 87卷 / 15期

关键词：

circadian rhythm; hypothalamus; transcription factor;

D O I：

10.1073/pnas.87.15.5959

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Mammalian circadian rhythmicity is endogenously generated by a pacemaker in the suprachiasmatic nuclei and precisely entrained to the 24-hr day/night cycle by periodic environmental light cues. We show that light alters the immunoreactive levels of a transcriptional regulatory protein, Fos, in the suprachiasmatic nuclei of albino rats. Photic regulation of Fos immunoreactivity does not occur in other retino-recipient brain areas except for the intergeniculate leaflet, which appears to be involved in mediating some of the complex effects of light on expressed circadian rhythms. Our results point to a promising new functional marker for the cellular effects of light and suggest that the expression of Fos or a related nuclear protein may be part of the mechanism for photic entrainment of the circadian clock to environmental light/dark cycles.

引用

页码：5959 / 5962

页数：4

共 63 条

[1] DAY NIGHT VARIATION IN PREPRO VASOACTIVE INTESTINAL PEPTIDE PEPTIDE HISTIDINE ISOLEUCINE MESSENGER-RNA WITHIN THE RAT SUPRACHIASMATIC NUCLEUS [J].