PAF ANTAGONIST GINKGOLIDE-B REDUCES POSTISCHEMIC NEURONAL DAMAGE IN RAT-BRAIN HIPPOCAMPUS

被引：101

作者：

OBERPICHLER, H

SAUER, D

ROSSBERG, C

MENNEL, HD

KRIEGLSTEIN, J

机构：

[1] UNIV MARBURG,INST PHARMACOL & TOXIKOL,FACHBEREICH PHARM & LEBENSMITTELCHEM,KETZERBACH 63,W-3550 MARBURG,GERMANY

[2] MED ZENTRUM PATHOL,NEUROPATHOL ABT,MARBURG,GERMANY

来源：

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM | 1990年 / 10卷 / 01期

关键词：

Delayed neuronal death; Ginkgolide B; Ischemia; Rat hippocampus;

D O I：

10.1038/jcbfm.1990.17

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We investigated the effect of the known antagonist of platelet-activating factor (PAF), ginkgolide B, on postischemic neuronal damage in the rat. Neuronal accroses were evaluated in the hippocampus 7 days after a 10-min forebrain ischemia. Preischemic application of ginkgolide B (50 mg/kg p.o.) significantly reduced neuronal damage. It is suggested that the antagonism of PAF is responsible for this beneficial effect of ginkgolide B.

引用

页码：133 / 135

页数：3

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