MOLECULAR CHARACTERIZATION OF A REGION OF DNA ASSOCIATED WITH MUTATIONS AT THE AGOUTI LOCUS IN THE MOUSE

被引：30

作者：

BULTMAN, SJ

RUSSELL, LB

GUTIERREZESPELETA, GA

WOYCHIK, RP

机构：

[1] OAK RIDGE NATL LAB,DIV BIOL,OAK RIDGE,TN 37831

[2] UNIV TENNESSEE,GRAD SCH BIOMED SCI,OAK RIDGE,TN 37831

[3] UNIV COSTA RICA,ESCUELA BIOL,SAN JOSE,COSTA RICA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1991年 / 88卷 / 18期

关键词：

RADIATION MUTAGENESIS; MOLECULAR ANALYSIS OF MUTATIONS;

D O I：

10.1073/pnas.88.18.8062

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Molecular characterization of a radiation-induced agouti (a)-locus mutation has resulted in the isolation of a segment of DNA that maps at or near the a locus on chromosome 2 in the mouse. This region of DNA is deleted in several radiation- or chemical-induced homozygous-lethal a-locus mutations and is associated with specific DNA structural alterations in two viable a-locus mutations. We propose that DNA probes from this region of chromosome 2 will be useful for ultimately characterizing the individual gene or genes associated with a-locus function.

引用

页码：8062 / 8066

页数：5

共 35 条

[1]

[Anonymous], ARCH ZOOL EXP GEN

[2]

Ausubel FM., 1988, CURRENT PROTOCOLS MO

[3]

BARSH GS, 1989, GENETICS, V121, P811

[4] THE LONG-RANGE RESTRICTION MAP SURROUNDING THE MOUSE AGOUTI LOCUS REVEALS A DISPARITY BETWEEN PHYSICAL AND GENETIC DISTANCES [J].