RIBOSOMAL PROTEIN CONFERRING SENSITIVITY TO ANTIBIOTIC SPECTINOMYCIN IN ESCHERICHIA COLI

被引：127

作者：

BOLLEN, A

DAVIES, J

OZAKI, M

MIZUSHIMA, S

机构：

[1] Biochemistry Department, University of Wisconsin, Madison

来源：

SCIENCE | 1969年 / 165卷 / 3888期

关键词：

D O I：

10.1126/science.165.3888.85

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Reconstitution of 30S ribosomal particles from 16S ribosomal RNA and total proteins, or from core proteins and split proteins obtained from the ribosomes of strains of Escherichia coli sensitive to and resistant to spectinomycin, shows that the split protein fraction determines the response of polypeptide synthesis in virto to spectinomycin. Reconstitution of active particles in the presence of isolated split proteins allowed the identification of the single split protein responsible for spectinomycin sensitivity.

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页码：85 / +

页数：1

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