L-DOPA AND CEREBROSPINAL FLUID HOMOVANILLIC ACID IN PARKINSONISM

被引：56

作者：

WEINER, W

HARRISON, W

KLAWANS, H

机构：

[1] Department of Neurology, Presbyterian-St. Luke's Hospital, Chicago, IL 60612

来源：

LIFE SCIENCES PART 1 PHYSIOLOGY AND PHARMACOLOGY AND PART 2 BIOCHEMISTRY GENERAL AND MOLECULAR BIOLOGY | 1969年 / 8卷 / 17P1期

关键词：

D O I：

10.1016/0024-3205(69)90428-7

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Lumbar cerebral spinal fluid of 19 patients with parkinsonism was analyzed for homovanillic acid before and during treatment with L-dopa. There was a marked rise in homovanillic acid concentration during treatment in all patients. This is the first indication that L-dopa results in increased utilizations of dopamine within the central nervous system. © 1969.

引用

页码：971 / &

共 11 条

[1]

ANDEN NE, 1963, LIFE SCI, V7, P448

[2] ON ORIGIN OF HOMOVANILLIC ACID IN CEREBROSPINAL FLUID [J].

BARTHOLI.G ;

PLETSCHE.A ;

TISSOT, R .

EXPERIENTIA, 1966, 22 (09) :609-&

[3]

Bernheimer H, 1966, Wien Klin Wochenschr, V78, P417

[4]

BERTLER A, 1966, PHARMACOL REV, V18, P369

[5]

EHRINGER, 1960, KLIN WSCHR, V38, P1236

[6]

GULDBERG HC, 1967, CONFIN NEUROL, V29, P73

[7] PARKINSONISM - ONSET PROGRESSION AND MORTALITY [J].

HOEHN, MM ;

YAHR, MD .

NEUROLOGY, 1967, 17 (05) :427-&

[8]

HORNYKIEWICZ O, 1966, PHARMACOL REV, V18, P925

[9]

KLAWANS HL, 1968, DIS NERV SYST, V29, P805

[10]

PLETSCHER A., 1967, BRAIN RES, V4, P106, DOI 10.1016/0006-8993(67)90154-0

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