EVOLUTIONARY FAMILIES OF PEPTIDASES

被引：675

作者：

RAWLINGS, ND

BARRETT, AJ

机构：

[1] Department of Biochemistry, Strangeways Research Laboratory, Cambridge CB1 4RN, Worts Causeway

来源：

BIOCHEMICAL JOURNAL | 1993年 / 290卷

关键词：

D O I：

10.1042/bj2900205

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The available amino acid sequences of peptidases have been examined, and the enzymes have been allocated to evolutionary families. Some of the families can be grouped together in 'clans' that show signs of distant relationship, but nevertheless, it appears that there may be as many as 60 evolutionary lines of peptidases with separate origins. Some of these contain members with quite diverse peptidase activities, and yet there are some striking examples of convergence. We suggest that the classification by families could be used as an extension of the current classification by catalytic type.

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页码：205 / 218

页数：14

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