GENETIC CONTROL OF 2 ELECTROPHORETIC VARIANTS OF GLUCOSEPHOSPHATE ISOMERASE IN MOUSE (MUS MUSCULUS)

The autosomal variation and the genetic control of GPI has been determined by a comparison of electrophoretic patterns of F1 and backcross progeny of three inbred strains of mice. The locus controlling the production of GPI in the mouse has been designated Gpi-1. Two alleles at this locus have been described and designated Gpi-1a and Gpi-1b, which represent, respectively, the slow and fast electrophoretic forms. Twenty-seven inbred strains of mice have been classified for these two alleles. The absence of close linkage of Gpi-1 to seven other genetic loci has been determined. It has been demonstrated that the polymorphism of Gpi-1 is widely distributed in feral mice. GPI was expressed in vitro and in four types of malignant tumors. © 1969 Plenum Publishing Corporation.