RELEASE OF ACETYLCHOLINE, GAMMA-AMINOBUTYRATE, DOPAMINE AND GLUTAMATE, AND ACTIVITY OF SOME RELATED ENZYMES, IN RAT GUSTATORY NEOCORTEX

被引：30

作者：

LOPEZGARCIA, JC ^{[1
]}

BERMUDEZRATTONI, F ^{[1
]}

TAPIA, R ^{[1
]}

机构：

[1] NATL AUTONOMOUS UNIV MEXICO,INST FISIOL CELULAR,DEPT NEUROCIENCIAS,APARTADO POSTAL 70-600,MEXICO CITY 04510,DF,MEXICO

来源：

BRAIN RESEARCH | 1990年 / 523卷 / 01期

关键词：

Acetylcholine; Glutamic acid; Gustatory neocortex; Neurotransmitter release; γ-Aminobutyric acid;

D O I：

10.1016/0006-8993(90)91640-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The gustatory neocortex (GN), final relay along the gustatory pathway, is a region of the brain involved in the neural integration of feeding behavior. Since information on the neurotransmitters in this nucleus is scarce, the aim of the present work was to establish whether acetylcholine (ACh), γ-aminobutyric acid (GABA), dopamine and glutamate may act as transmitters within this structure. It was found that GN slices are able to release labeled GABA, ACh and glutamate but not dopamine. Additionally, it was possible to detect significant glutamic acid decarboxylase, choline acetyltransferase and acetylcholinesterase activities in GN homogenates. The activity of the two enzymes involved in acetylcholine metabolism was higher than that observed in other cortical regions. These findings suggest that GABA, ACh and glutamate probably are neurotransmitters in the GN, whereas dopamine is not. © 1990.

引用

页码：100 / 104

页数：5

共 27 条

[1]

ALBERS RW, 1959, J BIOL CHEM, V234, P926

[2]

ASTROM KE, 1953, ACTA PHYSL SCAND S, V106, P309

[3]

BRAUN JJ, 1982, PHYSIOL PSYCHOL, V10, P13

[4] BEHAVIORAL, BIOCHEMICAL AND HISTOCHEMICAL EFFECTS OF DIFFERENT NEUROTOXIC AMINO-ACIDS INJECTED INTO NUCLEUS BASALIS MAGNOCELLULARIS OF RATS [J].