SYNERGISTIC INHIBITION OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 REPLICATION BY 5-ETHYL-1-ETHOXYMETHYL-6-(PHENYLTHIO)URACIL (E-EPU) AND AZIDOTHYMIDINE INVITRO

被引：21

作者：

BABA, M

ITO, M

SHIGETA, S

TANAKA, H

MIYASAKA, T

UBASAWA, M

UMEZU, K

WALKER, RT

DECLERCQ, E

机构：

[1] SHOWA UNIV,DEPT SYNTHET CHEM,TOKYO 142,JAPAN

[2] MITSUBISHI KASEI CORP,RES CTR,YOKOHAMA 227,JAPAN

[3] UNIV BIRMINGHAM,DEPT CHEM,BIRMINGHAM B15 2TT,W MIDLANDS,ENGLAND

[4] CATHOLIC UNIV LEUVEN,REGA INST MED RES,B-3000 LOUVAIN,BELGIUM

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1991年 / 35卷 / 07期

关键词：

D O I：

10.1128/AAC.35.7.1430

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A novel 6-substituted acyclouridine derivative, 5-ethyl-1-ethoxymethyl-6-(phenylthio)uracil (E-EPU), has recently proved to be a highly potent and selective inhibitor of human immunodeficiency virus type 1 (HIV-1) in vitro. Combinations of 3'-azido-2',3'-dideoxythymidine (AZT) and E-EPU synergistically inhibit the replication of HIV-1 in MT-4 cells, whereas the cytotoxic effects of AZT and E-EPU on mock-infected MT-4 cells are not enhanced by the drug combination. Synergistic inhibition of HIV-1 replication has also been observed in peripheral blood lymphocytes. These results indicate that the combination of AZT and E-EPU should be further pursued in the treatment of AIDS.

引用

收藏

页码：1430 / 1433

页数：4

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