HEMOGLOBIN - A LIFESAVER AND AN OXIDANT HOW TO TIP THE BALANCE

被引：35

作者：

FAASSEN, AE ^{[1
]}

SUNDBY, SR ^{[1
]}

PANTER, SS ^{[1
]}

CONDIE, RM ^{[1
]}

HEDLUND, BE ^{[1
]}

机构：

[1] UNIV MINNESOTA, DEPT SURG, MINNEAPOLIS, MN 55455 USA

来源：

BIOMATERIALS ARTIFICIAL CELLS AND ARTIFICIAL ORGANS | 1988年 / 16卷 / 1-3期

关键词：

Biopolymers--Antioxidants - Chemical Reactions--Chelation - Lipids--Oxidation;

D O I：

10.3109/10731198809132559

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Hemoglobin solutions were assessed in terms of their ability to promote lipid peroxidation, which was quantitated by measuring the formation of thiobarbituric acid reactive substances under specified conditions in murine brain homogenates. Solutions designed for use in acute treatment of hypovolemic shock and trauma should incorporate ingredients specifically aimed at decreasing oxygen and lipid radical mediated injury occurring secondary to ischemia and reperfusion. A number of strategies aimed at decreasing the oxidant effect of hemoglobin solutions and other blood and plasma substitues have been evaluated. These include use of the naturally occurring antioxidants in human plasma, specifically transferrin and ceruloplasmin. Similarly, certain iron chelators, such as deferoxamine, effectively prevent molecular and cellular damage caused by iron catalyzed formation of oxygen-derived radicals.

引用

页码：93 / 104

页数：12

共 26 条

[1] EVIDENCE FOR A REVERSIBLE OXYGEN RADICAL MEDIATED COMPONENT OF REPERFUSION INJURY - REDUCTION BY RECOMBINANT HUMAN SUPEROXIDE-DISMUTASE ADMINISTERED AT THE TIME OF REFLOW [J].