C-FOS AND C-MYC EXPRESSION IN HUMAN ENDOTHELIAL-CELLS AS A FUNCTION OF DIFFERENT CULTURE CONDITIONS

被引：11

作者：

LAMPUGNANI, MG

POLENTARUTTI, N

PEDENOVI, M

MANTOVANI, A

DEJANA, E

COLOTTA, F

机构：

[1] Istituto di Ricerche Farmacologiche Mario Negri, 20157 Milan

来源：

EXPERIMENTAL CELL RESEARCH | 1990年 / 186卷 / 02期

关键词：

D O I：

10.1016/0014-4827(90)90320-A

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cultured human umbilical vein endothelial cells (HEC) could be induced to express c-fos and c-myc mRNA by either serum or ECGS (endothelial cell growth supplement). Neither agonist separately could support HEC proliferation but the combination did. Expression of c-fos and c-myc mRNA in the presence of both serum and ECGS was similar to that observed after each of the two stimuli was introduced separately. c-fos and c-myc expression in cultured HEC, even if related, is not necessarily accompanied by stimulation of cell growth. © 1990.

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页码：381 / 384

页数：4

相关论文

共 23 条

[1]

BALCONI G, 1986, MED BIOL, V64, P231

[2]

BARBIERI B, 1981, P SOC EXP BIOL MED, V168, P204

[3] EXPRESSION OF C-FOS IN NIH3T3 CELLS IS VERY LOW BUT INDUCIBLE THROUGHOUT THE CELL-CYCLE [J].

BRAVO, R ;

BURCKHARDT, J ;

CURRAN, T ;

MULLER, R .

EMBO JOURNAL, 1986, 5 (04) :695-700

[4] EXPRESSION OF THE C-FOS GENE AND OF AN FOS-RELATED GENE IS STIMULATED BY PLATELET-DERIVED GROWTH-FACTOR [J].

COCHRAN, BH ;

ZULLO, J ;

VERMA, IM ;

STILES, CD .

SCIENCE, 1984, 226 (4678) :1080-1082

[5] INTERLEUKIN-1 INDUCES C-FOS PROTOONCOGENE EXPRESSION IN CULTURED HUMAN-ENDOTHELIAL CELLS [J].

COLOTTA, F ;

LAMPUGNANI, MG ;

POLENTARUTTI, N ;

DEJANA, E ;

MANTOVANI, A .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1988, 152 (03) :1104-1110

[6] C-MYC GENE-EXPRESSION IS STIMULATED BY AGENTS THAT ACTIVATE PROTEIN KINASE-C AND DOES NOT ACCOUNT FOR THE MITOGENIC EFFECT OF PDGF [J].

COUGHLIN, SR ;

LEE, WMF ;

WILLIAMS, PW ;

GIELS, GM ;

WILLIAMS, LT .

CELL, 1985, 43 (01) :243-251

[7] EXTREME INSTABILITY OF MYC MESSENGER-RNA IN NORMAL AND TRANSFORMED HUMAN-CELLS [J].

DANI, C ;

BLANCHARD, JM ;

PIECHACZYK, M ;

ELSABOUTY, S ;

MARTY, L ;

JEANTEUR, P .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (22) :7046-7050

[8] PRIMARY STRUCTURE OF BOVINE PITUITARY BASIC FIBROBLAST GROWTH-FACTOR (FGF) AND COMPARISON WITH THE AMINO-TERMINAL SEQUENCE OF BOVINE BRAIN ACIDIC FGF [J].

ESCH, F ;

BAIRD, A ;

LING, N ;

UENO, N ;

HILL, F ;

DENOROY, L ;

KLEPPER, R ;

GOSPODAROWICZ, D ;

BOHLEN, P ;

GUILLEMIN, R .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (19) :6507-6511

[9] ANGIOGENIC FACTORS [J].

FOLKMAN, J ;

KLAGSBRUN, M .

SCIENCE, 1987, 235 (4787) :442-447

[10] C-JUN DIMERIZES WITH ITSELF AND WITH C-FOS, FORMING COMPLEXES OF DIFFERENT DNA-BINDING AFFINITIES [J].

HALAZONETIS, TD ;

GEORGOPOULOS, K ;

GREENBERG, ME ;

LEDER, P .

CELL, 1988, 55 (05) :917-924