EFFECT OF HIGH-DOSE OXPRENOLOL ON STRESS-INDUCED PHYSICAL AND PSYCHOPHYSIOLOGICAL VARIABLES

被引：25

作者：

FARHOUMAND, N

HARRISON, J

PARE, CMB

TURNER, P

WYNN, S

机构：

[1] ST BARTHOLOMEWS HOSP,DEPT CLIN PHARMACOL,LONDON EC1,ENGLAND

[2] CIBA LABS,DEPT STAT,HORSHAM RH12 4AB,SUSSEX,ENGLAND

来源：

PSYCHOPHARMACOLOGY | 1979年 / 64卷 / 03期

关键词：

Beta-adrenoceptor blockade; CNS function tests;

D O I：

10.1007/BF00427526

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effects of oral oxprenolol (480 mg) and lorazepam (2 mg) on skin conductance, reaction time, critical flicker frequency and self-rating visual analogue scales for anxiety, sedation and concentration were investigated in 6 healthy male volunteers. Oxprenolol exerted a central action similar to lorazepam as shown by a significant lowering of skin conductance and decrease in the number of spontaneous fluctuations during stress, impaired critical flicker frequency and decrease in alertness with reduced concentration. © 1979 Springer-Verlag.

引用

页码：365 / 369

页数：5

共 21 条

[1] PROPRANOLOL ON TESTS OF VISUAL FUNCTION AND CENTRAL NERVOUS ACTIVITY [J].