STEROID RESEARCH AT SYNTEX - THE PILL AND CORTISONE

被引：60

作者：

DJERASSI, C

机构：

[1] Department of Chemistry, Stanford University, Stanford, CA

来源：

STEROIDS | 1992年 / 57卷 / 12期

关键词：

STEROIDS; SYNTEX; ORAL CONTRACEPTIVES; CORTISONE; NORETHINDRONE; NORETHYNODREL;

D O I：

10.1016/0039-128X(92)90016-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The period from late 1949 through 1951 was an extraordinarily productive one in steroid chemistry and especially so at Syntex S.A. in Mexico City. Two of the most important Syntex contributions-the synthesis of 19-nor-17alpha-ethynyltestosterone (norethindrone) and of cortisone from diosgenin-are described from a historical perspective.

引用

收藏

页码：631 / 641

页数：11

相关论文

共 52 条

[1] 10 nor-progesterone, a physiologically active lower homolog of progesterone [J].

Allen, WM ;

Ehrenstein, M .

SCIENCE, 1944, 100 :251-252

[2] The total synthesis of the sex hormone equilenin and its stereoisomers [J].

Bachmann, WE ;

Cole, W ;

Wilds, AL .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1940, 62 :824-839

[3]

BIRCH AJ, 1950, ANNU REP PROGR CHEM, V47, P177

[4] 17-ALKYL-19-NORTESTOSTERONES [J].

COLTON, FB ;

NYSTED, LN ;

RIEGEL, B ;

RAYMOND, AL .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1957, 79 (05) :1123-1127

[5]

COLTON FB, 1955, Patent No. 2725389

[6] STEROIDS .54. SYNTHESIS OF 19-NOR-17-ALPHA-ETHYNYLTESTOSTERONE AND 19-NOR-17-ALPHA-METHYLTESTOSTERONE [J].

DJERASSI, C ;

MIRAMONTES, L ;

ROSENKRANZ, G ;

SONDHEIMER, F .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1954, 76 (16) :4092-4094

[7] THE BROMINATION OF 3-KETOSTEROIDS IN ACETIC ACID AND THE EFFECT OF TRACE SUBSTANCES IN THE SOLVENT [J].

DJERASSI, C ;

SCHOLZ, CR .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1947, 69 (10) :2404-2410

[8] STEROIDAL SAPOGENINS .8. STEROIDS .18. SYNTHESIS OF DELTA-7,9(11)-ALLOPREGNADIEN-3BETA-OL-20-ONE FROM DIOSGENIN AND FROM DELTA-5-PREGNEN-3BETA-OL-20-ONE [J].

DJERASSI, C ;

ROMO, J ;

ROSENKRANZ, G .

JOURNAL OF ORGANIC CHEMISTRY, 1951, 16 (05) :754-760

[9] STEROIDAL SAPOGENINS .16. INTRODUCTION OF THE 11-KETO AND 11-ALPHA-HYDROXY GROUPS INTO RING-C UNSUBSTITUTED STEROIDS .3. 11-OXYGENATED SAPOGENINS [J].

DJERASSI, C ;

BATRES, E ;

VELASCO, M ;

ROSENKRANZ, G .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1952, 74 (07) :1712-1715

[10] STEROID ORAL CONTRACEPTIVES [J].

DJERASSI, C .

SCIENCE, 1966, 151 (3714) :1055-+

← 1 2 3 4 5 6 →