MK-801 REDUCED CEREBRAL ISCHEMIC-INJURY BY INDUCING HYPOTHERMIA

被引：212

作者：

CORBETT, D ^{[1
]}

EVANS, S ^{[1
]}

THOMAS, C ^{[1
]}

WANG, D ^{[1
]}

JONAS, RA ^{[1
]}

机构：

[1] HARVARD UNIV,CHILDRENS HOSP,BOSTON,MA 02115

来源：

BRAIN RESEARCH | 1990年 / 514卷 / 02期

关键词：

Cerebral Protection; Hypothermia; Ischemia; MK-801; N-Methyl-d-aspartate;

D O I：

10.1016/0006-8993(90)91424-F

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The non-competitive N-methyl-d-aspartate (NMDA) antagonist, MK-801, has been reported to prevent or attenuate ischermic brain damage in various animal models. In halothane-anesthetized gerbils it was found that an optimal dose of MK-801 (3.0 mg/kg) for providing cerebral protection also produced hypothermia (31.1 ± 0.62 °C) relative to control animals (34.2 ± 0.77 °C, P < 0.01). This degree of hypothermia alone was sufficient to provide complete histological and functional protection (spatial memory) against 5 min of carotid artery occlusion. In gerbils made ischemic, but maintained at normal body temperature, a dose of 3.0 mg/kg of MK-801 provided no provided no protection against hippocampal cell loss or spatial memory impairment. These data suggest that the protective actions of MK-801 may be due entirely to drug-induced hypothermia. © 1990.

引用

页码：300 / 304

页数：5

共 19 条

[1] THE N-METHYL-D-ASPARTATE ANTAGONISTS CGS-19755 AND CPP REDUCE ISCHEMIC BRAIN-DAMAGE IN GERBILS [J].