DECREASED SENSITIVITY TO INTERFERON ASSOCIATED WITH INVITRO TRANSFORMATION OF X-RAY-TRANSFORMED C3H-10T1-2 CELLS

被引：21

作者：

BROUTYBOYE, D

GRESSER, I

BALDWIN, C

机构：

[1] Institut de Recherches Scientifiques Sur Le Cancer, Villejuif

来源：

INTERNATIONAL JOURNAL OF CANCER | 1979年 / 24卷 / 02期

关键词：

D O I：

10.1002/ijc.2910240219

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We have compared the interferon sensitivity of parental 10T1/2 cells, having a phenotype characteristic of normal cells, with that of transformed cells isolated after X‐irradiation or treatment with methylcholanthrene. Transformed cells were 10‐ to 20‐fold less sensitive than the parental untransformed cells to the antiviral action of interferon and were also less sensitive to the inhibitory effect of interferon on cell multiplication. The decreased sensitivity of these cells to interferon is a useful marker of the transformed phenotype. Copyright © 1979 Wiley‐Liss, Inc., A Wiley Company

引用

页码：261 / 265

页数：5

共 15 条

[1]

BERTRAM JS, 1977, CANCER RES, V37, P514

[2] DECREASED INTERFERON SENSITIVITY AND PRODUCTION IN CELLS TRANSFORMED BY SV40 AND OTHER ONCOGENIC AGENTS [J].