THE SEC AND PRL GENES OF ESCHERICHIA-COLI

被引:157
作者
BIEKER, KL
PHILLIPS, GJ
SILHAVY, TJ
机构
[1] Department of Biology, Princeton University, Princeton, 08544, New Jersey
关键词
gene fusions; hybrid proteins; Protein secretion; signal sequence; suppressors;
D O I
10.1007/BF00763169
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
Two general approaches have been used to define genetically the genes that encode components of the cellular protein export machinery. One of these strategies identifies mutations that confer a conditional-lethal, pleiotropic export defect (sec, secretion). The other identifies dominant suppressors of signal sequence mutations (prl, protein localization). Subsequent characterization reveals that in at least three cases, prlA/secY, prlD/secA, and prlG/secE, both types of mutations are found within the same structural gene. This convergence is satisfying and provides compelling evidence for direct involvement of these gene products in the export process. © 1990 Plenum Publishing Corporation.
引用
收藏
页码:291 / 310
页数:20
相关论文
共 73 条
[1]   PROPER INTERACTION BETWEEN AT LEAST 2 COMPONENTS IS REQUIRED FOR EFFICIENT EXPORT OF PROTEINS TO THE ESCHERICHIA-COLI CELL-ENVELOPE [J].
BANKAITIS, VA ;
BASSFORD, PJ .
JOURNAL OF BACTERIOLOGY, 1985, 161 (01) :169-178
[2]  
BASSFORD P, 1979, NATURE, V277, P538, DOI 10.1038/277538a0
[3]  
BASSFORD PJ, 1979, J BACTERIOL, V139, P19, DOI 10.1128/JB.139.1.19-31.1979
[4]  
BEDOUELLE H, 1988, EUR J BIOCHEM, V171, P341
[5]  
BEDOUELLE H, 1981, NATURE, V258, P78
[6]   ISOLATION AND CHARACTERIZATION OF OUTER-MEMBRANE PERMEABILITY MUTANTS IN ESCHERICHIA-COLI K-12 [J].
BENSON, SA ;
DECLOUX, A .
JOURNAL OF BACTERIOLOGY, 1985, 161 (01) :361-367
[7]  
BENSON SA, 1985, ANNU REV BIOCHEM, V54, P101
[8]   PRLA IS IMPORTANT FOR THE TRANSLOCATION OF EXPORTED PROTEINS ACROSS THE CYTOPLASMIC MEMBRANE OF ESCHERICHIA-COLI [J].
BIEKER, KL ;
SILHAVY, TJ .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (03) :968-972
[9]   TRANSFER OF PROTEINS ACROSS MEMBRANES .1. PRESENCE OF PROTEOLYTICALLY PROCESSED AND UNPROCESSED NASCENT IMMUNOGLOBULIN LIGHT-CHAINS ON MEMBRANE-BOUND RIBOSOMES OF MURINE MYELOMA [J].
BLOBEL, G ;
DOBBERSTEIN, B .
JOURNAL OF CELL BIOLOGY, 1975, 67 (03) :835-851
[10]   THE USE OF EXTRAGENIC SUPPRESSORS TO DEFINE GENES INVOLVED IN PROTEIN EXPORT IN ESCHERICHIA-COLI [J].
BRICKMAN, ER ;
OLIVER, DB ;
GARWIN, JL ;
KUMAMOTO, C ;
BECKWITH, J .
MOLECULAR & GENERAL GENETICS, 1984, 196 (01) :24-27