NIGROSTRIATAL LESIONS ENHANCE STRIATAL APOMORPHINE-H-3 AND H-3-SPIROPERIDOL BINDING

被引：231

作者：

CREESE, I

SNYDER, SH

机构：

[1] JOHNS HOPKINS UNIV,SCH MED,DEPT EXPTL THERAPEUT,BALTIMORE,MD 21205

[2] JOHNS HOPKINS UNIV,SCH MED,DEPT PSYCHIAT,BALTIMORE,MD 21205

[3] JOHNS HOPKINS UNIV,SCH MED,DEPT PHARMACOL,BALTIMORE,MD 21205

[4] JOHNS HOPKINS UNIV,SCH MED,DEPT BEHAV SCI,BALTIMORE,MD 21205

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1979年 / 56卷 / 03期

关键词：

!sup]3[!/sup]H-Apomorphine binding; !sup]3[!/sup]H-Spiroperidol binding; Dopamine receptor; Supeesensitivity;

D O I：

10.1016/0014-2999(79)90184-5

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

3ollowing unilateral 6-hydroxydopamine nigrostriatal lesions in rats, the binding of both 3H-apomorphine and 3H-spiroperidol in the striatum is increased. In rats with incomplete lesions or at early time points after lesion, binding is not significantly different from control levels. © 1979.

引用

页码：277 / 281

页数：5

共 11 条

[1]

COYLE JT, 1972, BIOCHEM PHARMACOL, V21, P1935, DOI 10.1016/0006-2952(72)90006-8

[2] DOPAMINE RECEPTOR-BINDING - SPECIFICITY, LOCALIZATION AND REGULATION BY IONS AND GUANYL NUCLEOTIDES [J].