ASTROCYTES ARE RESPONSIVE TO ENDOTHELIUM-DERIVED RELAXING FACTOR (EDRF)

被引：13

作者：

ISHIZAKI, Y

MA, LJ

MORITA, I

MUROTA, SI

机构：

[1] Section of Physiological Chemistry, Faculty of Dentistry, Tokyo Medical and Dental University, Tokyo

来源：

NEUROSCIENCE LETTERS | 1991年 / 125卷 / 01期

关键词：

D O I：

10.1016/0304-3940(91)90122-A

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effects of endothelium-derived relaxing factor (EDRF) and sodium nitroprusside (SNP), which produces nitric oxide (NO) spontaneously, on cultured astrocytes prepared from cerebra of rat embryos were examined. EDRF produced by vascular endothelial cells in response to bradykinin stimulation, caused a significant rise in cyclic GMP levels of astrocytes. SNP also increased cyclic GMP levels of astrocytes in a dose-dependent way. These results revealed for the first time unambiguously that astrocytes are responsive to EDRF.

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页码：29 / 30

页数：2

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