SITE-SPECIFIC INCORPORATION OF NONNATURAL RESIDUES INTO PEPTIDES - EFFECT OF RESIDUE STRUCTURE ON SUPPRESSION AND TRANSLATION EFFICIENCIES

被引：63

作者：

BAIN, JD ^{[1
]}

WACKER, DA ^{[1
]}

KUO, EE ^{[1
]}

CHAMBERLIN, AR ^{[1
]}

机构：

[1] UNIV CALIF IRVINE,DEPT CHEM,IRVINE,CA 92717

来源：

TETRAHEDRON | 1991年 / 47卷 / 14-15期

关键词：

D O I：

10.1016/S0040-4020(01)81776-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A systematic survey of the structural requirements for biosynthetic incorporation of non-natural residues into a polypeptide is presented. Relative translation efficiencies for a series of 12 semi-synthetic acylated suppressor tRNAs ranged from 0 to 91% depending on the structure of the residue incorporated.

引用

收藏

页码：2389 / 2400

页数：12

相关论文

共 36 条

[1] SYNTHESIS OF CYCLOHEXYLPUROMYCIN AND ITS REACTION WITH N-ACETYLPHENYLALANYL-TRANSFER RIBONUCLEIC-ACID ON RAT-LIVER RIBOSOMES [J].

ARIATTI, M ;

HAWTREY, AO .

BIOCHEMICAL JOURNAL, 1975, 145 (02) :169-176

[2] BIOSYNTHETIC SITE-SPECIFIC INCORPORATION OF A NON-NATURAL AMINO-ACID INTO A POLYPEPTIDE [J].

BAIN, JD ;

GLABE, CG ;

DIX, TA ;

CHAMBERLIN, AR ;

DIALA, ES .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1989, 111 (20) :8013-8014

[3]

BAIN JD, 1990, UNPUB J ORG CHEM

[4]

BAIN JD, 1990, UNPUB BIOCHEMISTRY

[5] MISCHARGING ESCHERICHIA-COLI TRANSFER RNAPHE WITH L-4'-[3-(TRIFLUOROMETHYL)-3H-DIAZIRIN-3-YL]PHENYLALANINE, A PHOTOACTIVATABLE ANALOG OF PHENYLALANINE [J].

BALDINI, G ;

MARTOGLIO, B ;

SCHACHENMANN, A ;

ZUGLIANI, C ;

BRUNNER, J .

BIOCHEMISTRY, 1988, 27 (20) :7951-7959

[6] ENZYMATIC REPLACEMENT OF THE ANTICODON OF YEAST PHENYLALANINE TRANSFER RIBONUCLEIC-ACID [J].

BRUCE, AG ;

UHLENBECK, OC .

BIOCHEMISTRY, 1982, 21 (05) :855-861

[7] CATALYTIC PROPERTIES OF TYROSYL RIBONUCLEIC ACID SYNTHETASES FROM ESCHERICHIA COLI AND BACILLUS SUBTILIS [J].

CALENDAR, R ;

BERG, P .

BIOCHEMISTRY, 1966, 5 (05) :1690-&

[8] 9-FLUORENYLMETHOXYCARBONYL AMINO-PROTECTING GROUP [J].

CARPINO, LA ;

HAN, GY .

JOURNAL OF ORGANIC CHEMISTRY, 1972, 37 (22) :3404-&

[9]

CELIS JE, 1979, NONSENSE MUTATIONS T

[10] ON ROLE OF SOLUBLE RIBONUCLEIC ACID IN CODING FOR AMINO ACIDS [J].

CHAPEVILLE, F ;

EHRENSTEIN, GV ;

BENZER, S ;

WEISBLUM, B ;

RAY, WJ ;

LIPMANN, F .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1962, 48 (06) :1086-&

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