THE TYPE-II DECOY RECEPTOR - A NOVEL REGULATORY PATHWAY FOR INTERLEUKIN-1

被引：315

作者：

COLOTTA, F

DOWER, SK

SIMS, JE

MANTOVANI, A

机构：

[1] UNIV BRESCIA,DEPT BIOTECHNOL,PATHOL SECT,I-25123 BRESCIA,ITALY

[2] IMMUNEX RES & DEV CORP,SEATTLE,WA 98101

来源：

IMMUNOLOGY TODAY | 1994年 / 15卷 / 12期

关键词：

D O I：

10.1016/0167-5699(94)90217-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The interleukin 1 (IL-1) system plays a central role in inflammation and immunity. Of the two receptors that bind IL-1, the type I receptor is known to mediate signaling activity: whereas the function of the type II receptor remains unknown. Here, Francesco Colotta and colleagues review the properties of these receptors and summarize evidence indicating that the type II receptor acts as a regulated decoy target for IL-1.

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页码：562 / 566

页数：5

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