SOLID-PHASE TUFTSIN (THR-LYS-PRO-ARG) SYNTHESIS - DEPROTECTION AND RESIN CLEAVAGE WITH TRIFLUOROMETHANE SULFONIC-ACID

被引：21

作者：

CHAUDHURI, MK ^{[1
]}

NAJJAR, VA ^{[1
]}

机构：

[1] TUFTS UNIV,SCH MED,DIV PROT CHEM,BOSTON,MA 02111

来源：

ANALYTICAL BIOCHEMISTRY | 1979年 / 95卷 / 01期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/0003-2697(79)90220-3

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A method is described for the synthesis of the naturally occurring tetrapeptide tuftsin (Thr-Lys-Pro-Arg). This stimulates phagocytosis of granulocytes and macrophages. Trifluoromethanesulfonic acid is used to cleave the tetrapeptide from its supporting resin in solid-phase synthesis. This reagent also causes deprotection of several protecting groups in bifunctional residues. The most significant is the complete removal of the tosyl group from NG-tosyl-arginine-resin ester. © 1979.

引用

页码：305 / 310

页数：6

共 15 条

[1] TUFTSIN AND SOME ANALOGS - SYNTHESIS AND INTERACTION WITH HUMAN POLYMORPHONUCLEAR LEUKOCYTES [J].