INHIBITION OF CO2 COMBINATION AND REDUCTION OF BOHR EFFECT IN HAEMOGLOBIN CHEMICALLY MODIFIED AT ITS ALPHA-AMINO GROUPS

被引：246

作者：

KILMARTIN, JV

ROSSIBER.L

机构：

[1] MRC Laboratory of Molecular Biology, Cambridge

[2] Istituto di Chimica Organica, University of Milan

来源：

NATURE | 1969年 / 222卷 / 5200期

关键词：

D O I：

10.1038/2221243a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Blocking of the α-amino groups by cyanate inhibits the uptake of CO2 by haemoglobin. It also inhibits the influence which changes in pCO2 at constant pH normally have on the oxygen affinity and on the Bohr effect. Blocking the α-amino groups of the α chain reduces the alkaline Bohr effect by 25 per cent. © 1969 Nature Publishing Group.

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页码：1243 / +

页数：1

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