EXPRESSION OF MURINE CD1 ON GASTROINTESTINAL EPITHELIUM

被引：216

作者：

BLEICHER, PA

BALK, SP

HAGEN, SJ

BLUMBERG, RS

FLOTTE, TJ

TERHORST, C

机构：

[1] MASSACHUSETTS GEN HOSP,CUTANEOUS BIOL RES CTR,BOSTON,MA 02114

[2] HARVARD UNIV,SCH MED,DANA FARBER CANC INST,MOLEC IMMUNOL LAB,BOSTON,MA 02115

[3] BETH ISRAEL HOSP,DEPT HEMATOL & ONCOL,BOSTON,MA 02215

[4] BRIGHAM & WOMENS HOSP,DEPT GASTROENTEROL,BOSTON,MA 02115

来源：

SCIENCE | 1990年 / 250卷 / 4981期

关键词：

D O I：

10.1126/science.1700477

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Cluster of differentiation 1 (CD1) in humans is a family of major histocompatibility complex (MHC) class I-like molecules expressed on the surface of immature thymocytes, Langerhans cells, and a subpopulation of B cells. The only function identified for human CD1 is as a ligand recognized by a subpopulation of T lymphocytes. In order to study the distribution and function of these molecules in the mouse, a murine CD1 complementary DNA was expressed in mouse fibroblasts and used to produce monoclonal antibodies. These antibodies revealed prominent expression of murine CD1 only on gastrointestinal tract epithelium and in the cytoplasm of hepatocytes. Low levels of expression were also detected on thymocytes and peripheral lymphocytes. The gastrointestinal distribution of murine CD1 suggests that this molecule may be important in epithelial immunity.

引用

页码：679 / 682

页数：4

共 42 条

[1] SENSITIVE AND HIGH-RESOLUTION INSITU HYBRIDIZATION TO HUMAN-CHROMOSOMES USING BIOTIN LABELED PROBES - ASSIGNMENT OF THE HUMAN THYMOCYTE CD1 ANTIGEN GENES TO CHROMOSOME-1 [J].