ALPHA-1-FETOPROTEIN PRODUCTION DURING THE HEPATOCYTE GROWTH-CYCLE OF DEVELOPING RAT-LIVER

被引：16

作者：

GUILLOUZO, A ^{[1
]}

BOISNARDRISSEL, M ^{[1
]}

BELANGER, L ^{[1
]}

BOUREL, M ^{[1
]}

机构：

[1] HOTEL DIEU,CTR RECH,CELLULAIRE & MOLEC LAB,QUEBEC CITY G1R 2J6,QUEBEC,CANADA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1979年 / 91卷 / 01期

关键词：

D O I：

10.1016/0006-291X(79)90621-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The relation of AFP production to DNA synthesis was investigated in newborn rat liver and in primary cultures of fetal rat hepatocytes, by combining immunoperoxidase AFP localization and autoradiography after 3H-thymidine labelling. The vast majority of AFP-positive hepatocytes did not incorporate 3H-thymidine after ≤4-h isotope pulses, suggesting that in the developing liver, essentially no production of AFP occurs in S, G2 or M phases of the hepatocyte cell life cycle. Serial or continuous thymidine labelling experiments further indicated that post-mitotic hepatocytes constitute a sizable fraction of AFP-producing cells. © 1979.

引用

页码：327 / 331

页数：5

共 24 条

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