DNAJ-LIKE PROTEINS - MOLECULAR CHAPERONES AND SPECIFIC REGULATORS OF HSP70

被引：415

作者：

CYR, DM ^{[1
]}

LANGER, T ^{[1
]}

DOUGLAS, MG ^{[1
]}

机构：

[1] UNIV N CAROLINA,SCH MED,DEPT BIOCHEM & BIOPHYS,CHAPEL HILL,NC 27599

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1994年 / 19卷 / 04期

基金：

澳大利亚研究理事会; 美国国家卫生研究院;

关键词：

D O I：

10.1016/0968-0004(94)90281-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The folding of proteins and the assembly of protein complexes within subcompartments of the eukaryotic cell is catalysed by different members of the Hsp70 protein family. The chaperone function of Hsp70 proteins in these events is regulated by members of the DnaJ-like protein family, which occurs through direct interaction of different Hsp70 and DnaJ-like protein pairs that appear to be specifically adapted to each other. This review highlights the diversity of functions of DnaJ-like proteins by using specific examples of DnaJ-Hsp70 interactions with polypeptides in yeast protein-biogenesis pathways.

引用

页码：176 / 181

页数：6

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