THE COMPLEXITIES OF EUKARYOTIC TRANSCRIPTION INITIATION - REGULATION OF PREINITIATION COMPLEX ASSEMBLY

被引：442

作者：

ROEDER, RG

机构：

[1] R.G. Roeder is at the Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, NY 10021

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1991年 / 16卷 / 11期

关键词：

D O I：

10.1016/0968-0004(91)90164-Q

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Individual steps in the assembly of RNA polymerase II and general initiation factors into a preinitiation complex serve as points of control for activators, whose functions require additional cofactors. The full range of induction by activators appears to involve both the reversal of negative constraints and net positive effects on promoter interactions with general factors.

引用

页码：402 / 408

页数：7

共 39 条

[1]

BRAETHNACH R, 1981, ANN REV BIOCH, V50, P349

[2] 5 INTERMEDIATE COMPLEXES IN TRANSCRIPTION INITIATION BY RNA POLYMERASE-II [J].