PROTEIN-KINASES

被引：63

作者：

GOLDSMITH, EJ

COBB, MH

机构：

[1] UNIV TEXAS, SW MED CTR, DEPT PHARMACOL, DALLAS, TX 75235 USA

[2] HOWARD HUGHES MED INST, DALLAS, TX USA

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 1994年 / 4卷 / 06期

关键词：

D O I：

10.1016/0959-440X(94)90264-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The structures of four serine/threonine protein kinases have been determined recently. By comparing these structures with that of the cAMP-dependent protein kinase (cAPK), it is now possible to see how the activity of these regulatory enzymes is controlled. Low activity is maintained through the conformation of the phosphorylation lip, domain rotations, and binding of substrate analog inhibitors and autoinhibitory domains.

引用

收藏

页码：833 / 840

页数：8

相关论文

共 57 条

[1] REQUIREMENT FOR INTEGRATION OF SIGNALS FROM 2 DISTINCT PHOSPHORYLATION PATHWAYS FOR ACTIVATION OF MAP KINASE [J].

ANDERSON, NG ;

MALLER, JL ;

TONKS, NK ;

STURGILL, TW .

NATURE, 1990, 343 (6259) :651-653

[2]

BENIAN GM, 1989, NATURE, V342, P47

[3] STRUCTURE OF A COMPLEX BETWEEN YEAST HEXOKINASE-A AND GLUCOSE .2. DETAILED COMPARISONS OF CONFORMATION AND ACTIVE-SITE CONFIGURATION WITH THE NATIVE HEXOKINASE-B MONOMER AND DIMER [J].

BENNETT, WS ;

STEITZ, TA .

JOURNAL OF MOLECULAR BIOLOGY, 1980, 140 (02) :211-230

[4] PHOSPHOTRANSFERASE AND SUBSTRATE BINDING MECHANISM OF THE CAMP-DEPENDENT PROTEIN-KINASE CATALYTIC SUBUNIT FROM PORCINE HEART AS DEDUCED FROM THE 2.0 ANGSTROM STRUCTURE OF THE COMPLEX WITH MN2+ ADENYLYL IMIDODIPHOSPHATE AND INHIBITOR PEPTIDE PKI(5-24) [J].

BOSSEMEYER, D ;

ENGH, RA ;

KINZEL, V ;

PONSTINGL, H ;

HUBER, R .

EMBO JOURNAL, 1993, 12 (03) :849-859

[5] IDENTIFICATION OF MULTIPLE EXTRACELLULAR SIGNAL-REGULATED KINASES (ERKS) WITH ANTIPEPTIDE ANTIBODIES [J].

BOULTON, TG ;

COBB, MH .

CELL REGULATION, 1991, 2 (05) :357-371

[6]

CORBIN JD, 1978, J BIOL CHEM, V253, P3997

[7] CRYSTAL-STRUCTURE OF CYCLIN-DEPENDENT KINASE-2 [J].

DEBONDT, HL ;

ROSENBLATT, J ;

JANCARIK, J ;

JONES, HD ;

MORGAN, DO ;

KIM, SH .

NATURE, 1993, 363 (6430) :595-602

[8]

DELAFUEN.G, 1970, EUR J BIOCHEM, V16, P226

[9] CDK INHIBITORS - ON THE THRESHOLD OF CHECKPOINTS AND DEVELOPMENT [J].

ELLEDGE, SJ ;

HARPER, JW .

CURRENT OPINION IN CELL BIOLOGY, 1994, 6 (06) :847-852

[10] IDENTIFICATION OF AN AUTOINHIBITORY DOMAIN IN THE INSULIN-RECEPTOR TYROSINE KINASE [J].

FILIPEK, A ;

SODERLING, TR .

MOLECULAR AND CELLULAR BIOCHEMISTRY, 1993, 120 (02) :103-110

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