ETHANOL EMBRYOTOXICITY - DIRECT EFFECTS ON MAMMALIAN EMBRYOS INVITRO

被引：202

作者：

BROWN, NA

GOULDING, EH

FABRO, S

机构：

[1] GEORGE WASHINGTON UNIV,MED CTR,DEPT PHARMACOL,WASHINGTON,DC 20037

[2] GEORGE WASHINGTON UNIV,MED CTR,DEPT OBSTET & GYNECOL,WASHINGTON,DC 20037

来源：

SCIENCE | 1979年 / 206卷 / 4418期

关键词：

D O I：

10.1126/science.573922

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Exposure to ethanol retards growth and differentiation in cultured rat embryos during organogenesis. The development of untreated embryos is indistinguishable from growth in utero. These data suggest that the hypoplastic features of children born to chronically alcoholic mothers are due, at least in part, to a direct action of ethanol, which causes reduced embryonic cellular proliferation early in gestation. Copyright © 1979 AAAS.

引用

页码：573 / 575

页数：3

共 24 条

[1]

BROWN NA, 1979, 26TH P ANN M SOC GYN, V132, pA219

[2]

BROWN NA, TOXICOL APPL PHARMAC

[3]

BROWN NL, UNPUBLISHED

[4] FETAL ALCOHOL SYNDROME [J].