LASER-INDUCED FLUORESCENCE DETECTION OF CARDIOVASCULAR ATHEROSCLEROTIC DEPOSITS VIA THEIR NATURAL EMISSION AND HYPOCRELLIN (HA) PROBING

被引：18

作者：

PAPAZOGLOU, TG ^{[1
]}

LIU, WQ ^{[1
]}

KATSAMOURIS, A ^{[1
]}

FOTAKIS, C ^{[1
]}

机构：

[1] UNIV CRETE,SCH MED,DEPT SURG,GR-71409 IRAKLION,GREECE

来源：

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY | 1994年 / 22卷 / 02期

关键词：

FLUORESCENCE; ARTERIOSCLEROSIS; HYPOCRELLIN; DISCRIMINATION;

D O I：

10.1016/1011-1344(93)06960-B

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In order to develop a reliable laser-induced-fluorescence-guided angioplasty system, fluorescence spectra were recorded during exposure of normal and atherosclerotic cadaveric aortic tissue to He-Cd laser radiation (442 nm). A characteristic increase in the fluorescence signal at 600 nm for atheromatous tissue was observed after treatment of the samples with hypocrellin (HA). This, combined with the spectral distribution of tissue natural fluorescence, allowed the development of simple algorithms, based on the intensity difference and the full width at half-maximum (FWHM), and a subsequent index of discrimination between normal and various atheromatous tissues. Our results suggest that monitoring of this index through the catheter could enhance selective ablation, reducing the risk of normal vessel perforation.

引用

页码：139 / 144

页数：6

共 15 条

[1] FLUORESCENCE-SPECTRA FROM CANCEROUS AND NORMAL HUMAN-BREAST AND LUNG TISSUES [J].

ALFANO, RR ;

TANG, GC ;

PRADHAN, A ;

LAM, W ;

CHOY, DSJ ;

OPHER, E .

IEEE JOURNAL OF QUANTUM ELECTRONICS, 1987, 23 (10) :1806-1811

[2] MULTISPECTRAL SYSTEM FOR MEDICAL FLUORESCENCE IMAGING [J].

ANDERSSON, PS ;

MONTAN, S ;

SVANBERG, S .

IEEE JOURNAL OF QUANTUM ELECTRONICS, 1987, 23 (10) :1798-1805

[3] CHLOROTETRACYCLINE-INDUCED FLUORESCENCE FROM ATHEROSCLEROTIC PLAQUE WITH UV LASER EXCITATION [J].

CLARKE, RH ;

CERIO, FM ;

ISNER, JM .

JOURNAL OF LUMINESCENCE, 1987, 39 (02) :87-96

[4] FLUORESCENCE SPECTROSCOPY GUIDANCE OF LASER ABLATION OF ATHEROSCLEROTIC PLAQUE [J].

DECKELBAUM, LI ;

STETZ, ML ;

OBRIEN, KM ;

CUTRUZZOLA, FW ;

GMITRO, AF ;

LAIFER, LI ;

GINDI, GR .

LASERS IN SURGERY AND MEDICINE, 1989, 9 (03) :205-214

[5]

GRYNKIEWICZ G, 1985, J BIOL CHEM, V260, P3440

[6] FLUORESCENCE SPECTROSCOPY OF TURBID MEDIA - AUTOFLUORESCENCE OF THE HUMAN AORTA [J].

KEIJZER, M ;

RICHARDSKORTUM, RR ;

JACQUES, SL ;

FELD, MS .

APPLIED OPTICS, 1989, 28 (20) :4286-4292

[7] DELAYED OBSERVATION OF LASER-INDUCED FLUORESCENCE FOR IMAGING OF TUMORS [J].

KOHL, M ;

NEUKAMMER, J ;

SUKOWSKI, U ;

RINNEBERG, H ;

WOHRLE, D ;

SINN, HJ ;

FRIEDRICH, EA .

APPLIED PHYSICS B-PHOTOPHYSICS AND LASER CHEMISTRY, 1993, 56 (03) :131-138

[8]

LAUFER G, 1989, LASER SURG MED, V9, P557

[9] HUMAN ARTERIAL SURFACE FLUORESCENCE - ATHEROSCLEROTIC PLAQUE IDENTIFICATION AND EFFECTS OF LASER ATHEROMA ABLATION [J].

LEON, MB ;

LU, DY ;

PREVOSTI, LG ;

MACY, WW ;

SMITH, PD ;

GRANOVSKY, M ;

BONNER, RF ;

BALABAN, RS .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1988, 12 (01) :94-102

[10] MULTICOLOR IMAGING AND CONTRAST ENHANCEMENT IN CANCER-TUMOR LOCALIZATION USING LASER-INDUCED FLUORESCENCE IN HEMATOPORPHYRIN-DERIVATIVE-BEARING TISSUE [J].

MONTAN, S ;

SVANBERG, K ;

SVANBERG, S .

OPTICS LETTERS, 1985, 10 (02) :56-58

← 1 2 →