INCREASED CONCENTRATIONS OF NITRITE IN SYNOVIAL-FLUID AND SERUM SAMPLES SUGGEST INCREASED NITRIC-OXIDE SYNTHESIS IN RHEUMATIC DISEASES

被引：641

作者：

FARRELL, AJ ^{[1
]}

BLAKE, DR ^{[1
]}

PALMER, RMJ ^{[1
]}

MONCADA, S ^{[1
]}

机构：

[1] WELLCOME RES LABS,BECKENHAM BR3 3BS,KENT,ENGLAND

来源：

ANNALS OF THE RHEUMATIC DISEASES | 1992年 / 51卷 / 11期

关键词：

D O I：

10.1136/ard.51.11.1219

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Cytokines induce nitric oxide synthesis by endothelial cells, macrophages and polymorphonuclear leucocytes, indicating a role for nitric oxide in inflammatory processes. Nitric oxide production was therefore measured indirectly as nitrite in serum and synovial fluid samples from patients with rheumatoid arthritis (RA) and osteoarthritis (OA) together with serum samples from healthy volunteers matched for age and sex. Serum nitrite concentrations in patients with RA and OA were significantly higher than in controls. In both disease groups synovial fluid nitrite was significantly higher than serum nitrite, implying nitric oxide synthesis by the synovium. Serum and synovial fluid nitrite concentrations in RA were also significantly higher than those in OA. These data show increased nitric oxide production in RA and OA and suggest a role for nitric oxide as an inflammatory mediator in rheumatic diseases.

引用

页码：1219 / 1222

页数：4

共 31 条

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