Defective phorbol ester-stimulated secretion of beta-amyloid precursor protein from Alzheimer's disease fibroblasts

被引：49

作者：

Bergamaschi, S

Binetti, G

Govoni, S

Wetsel, WC

Battaini, F

Trabucchi, M

Bianchetti, A

Racchi, M

机构：

[1] UNIV MILAN,INST PHARMACOL SCI,I-20133 MILAN,ITALY

[2] OSPED S CUORE GESU,ALZHEIMERS DIS RES UNIT,BRESCIA,ITALY

[3] UNIV PAVIA,INST PHARMACOL,I-27100 PAVIA,ITALY

[4] NIEHS,RES TRIANGLE PK,NC 27709

[5] UNIV ROMA TOR VERGATA,DEPT EXPTL MED & BIOCHEM SCI,ROME,ITALY

[6] OSPED S CUORE GESU,CELLULAR & MOLEC NEUROBIOL LAB,BRESCIA,ITALY

来源：

NEUROSCIENCE LETTERS | 1995年 / 201卷 / 01期

关键词：

Alzheimer's disease; human skin fibroblasts; amyloid precursor protein; protein kinase C; phorbol esters;

D O I：

10.1016/0304-3940(95)12168-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The present study shows that cultured fibroblasts from sporadic Alzheimer's disease patients are deficient in protein kinase C-regulated secretion of amyloid precursor protein. In particular, Alzheimer fibroblasts show a reduced basal secretion and a reduced response at low concentrations of phorbol-12,13-dibutyrate, with an EC(50) twofold higher than control fibroblasts. Furthermore, we observed that such defective regulation of the amyloid precursor secretion can possibly bi: correlated to a specific defect in protein kinase C alpha in fibroblasts from Alzheimer patients.

引用

页码：1 / 4

页数：4

共 22 条

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