PLASMA CORTICOSTERONE RESPONSES TO STRESS FOLLOWING CHRONIC ORAL-ADMINISTRATION OF DIAZEPAM IN THE RAT

The effect of daily, oral administration of diazepam on plasma corticosterone responses to stressors of varying intensity was investigated. In rats exposed to the mild stress of noise, diazepam, 10 mg kg−1 but not 1.0 or 0.1 mg kg−1, reduced plasma corticosterone concentrations by 30% in comparison with controls. However, in rats exposed to the more severe stressors, foot‐shock or immobilization, none of these doses of diazepam reduced plasma corticosterone responses. In unstressed rats, diazepam 10 mg kg−1 raised plasma corticosterone concentrations. It is suggested that plasma corticosterone concentrations are not a reliable indicator of the tranquillizing effect of diazepam during stress. 1979 Royal Pharmaceutical Society of Great Britain