GROWTH-FACTORS AS MORPHOGENS - DO GRADIENTS AND THRESHOLDS ESTABLISH BODY PLAN

Theories of morphogenesis have centered around gradients of morphogens interpreted by cells according to preset concentration thresholds. Growth factor proteins have been candidates for such morphogens, and experiments in the frog Xenopus, among other organisms, now show that embryonic cells are capable of interpreting growth factor concentrations according to the models. This opens up questions of whether such mechanisms are sufficient, and - if there are growth factor gradients - which factors are actually used and how.