POSTISCHEMIC GLUCOSE-UTILIZATION IN RAT HIPPOCAMPAL LAYERS

被引：8

作者：

BECK, T

WREE, A

SCHLEICHER, A

机构：

[1] UNIV MARBURG,INST NEPHROL,W-3550 MARBURG,GERMANY

[2] UNIV COLOGNE,INST ANAT,W-5000 COLOGNE 41,GERMANY

[3] UNIV WURZBURG,INST ANAT,W-8700 WURZBURG,GERMANY

来源：

BRAIN RESEARCH | 1990年 / 510卷 / 01期

关键词：

Cerebral ischemia; Hippocampus; Local cerebral glucose utilization; Long-term recovery; Rat;

D O I：

10.1016/0006-8993(90)90729-U

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The influence on hippocampal glucose utilization was determined in male Wistar rats 7 days after a 10-min forebrain ischemia. Ischemia was induced by clamping of the carotid arteries and lowering blood pressure to 40 mm Hg. Despite severe neuronal damage as assessed by histological techniques, local cerebral glucose utilization (LCGU) was significantly increased in the pyramidal and radiatum layer of the CA1 sector, while in layers of the CA2, CA3 and CA4 sector and dentate gyrus, LCGU was reduced compared to non-ischemic controls. The increases in LCGU are suggested to reflect long-lasting hyperexcitation in the selectively vulnerable CA1 sector, implicating a correlation between cellular hypermetabolism and neuronal damage. © 1990.

引用

页码：74 / 83

页数：10

共 59 条

[1] CALCIUM-UPTAKE EVOKED BY ELECTRICAL-STIMULATION IS ENHANCED POSTISCHEMICALLY AND PRECEDES DELAYED NEURONAL DEATH IN CA1 OF RAT HIPPOCAMPUS - INVOLEMENT OF N-METHYL-D-ASPARTATE RECEPTORS [J].