TGF-BETA STIMULATION OF ENDOMETRIAL AND BREAST-CANCER CELL-GROWTH

被引：26

作者：

CROXTALL, JD

JAMIL, A

AYUB, M

COLLETTA, AA

WHITE, JO

机构：

[1] ROYAL POSTGRAD MED SCH, INST GYNAECOL & OBSTET, LONDON W12 0HS, ENGLAND

[2] KINGS COLL, SCH MED, RAYNE INST, DEPT SURG, LONDON SE5 9NU, ENGLAND

来源：

INTERNATIONAL JOURNAL OF CANCER | 1992年 / 50卷 / 05期

关键词：

D O I：

10.1002/ijc.2910500527

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Growth of the human endometrial carcinoma Ishikawa cell line was stimulated by transforming growth factor-beta-1 when cultured in serum-containing and chemically defined culture medium. This response was not unique to endometrial carcinoma cells, as the breast-cancer cell line, T47-D, was similarly stimulated by TGF-beta-1, TGF-beta-1, stimulated growth of MCF-7 breast-cancer cells in chemically defined medium but inhibited growth of this cell line in serum-containing medium. The data provide a demonstration of a positive growth response to TGF-beta-1 in oestrogen-receptor-positive cells and do not support the hypothesis that this growth factor is simply a negative growth regulator in epithelial-cancer cell lines.

引用

页码：822 / 827

页数：6

共 35 条

[1]

ANZAI Y, 1989, CANCER RES, V49, P2362

[2]

ARRICK BA, 1990, CANCER RES, V50, P299

[3]

ARTEAGA CL, 1988, CANCER RES, V48, P3898

[4]

ASSOIAN RK, 1985, J BIOL CHEM, V260, P9613