SOMATIC GENE-THERAPY FOR CARDIOVASCULAR-DISEASE - RECENT ADVANCES

被引：14

作者：

BARR, E ^{[1
]}

LEIDEN, JM ^{[1
]}

机构：

[1] UNIV CHICAGO, DEPT PATHOL, CHICAGO, IL 60637 USA

来源：

TRENDS IN CARDIOVASCULAR MEDICINE | 1994年 / 4卷 / 02期

关键词：

D O I：

10.1016/1050-1738(94)90010-8

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The recent development of several novel approaches for in vivo gene transfer into the coronary arteries and myocardium has led to new possibilities for the treatment of both acquired and inherited cardiovascular diseases. This review summarizes the current state of the art of in vivo gene transfer into the heart and coronary arteries with particular emphasis on antisense oligonucleotide-mediated suppression of gene expression in vascular smooth muscle cells, liposome-mediated gene transfer into the vasculature, and percutaneous transluminal gene transfer (PTGT) into the heart with the use of replication-defective adenoviruses.

引用

页码：57 / 63

页数：7

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