URINARY NEOPTERIN IN VOLUNTEERS EXPERIMENTALLY INFECTED WITH PLASMODIUM-FALCIPARUM

被引：9

作者：

BROWN, AE ^{[1
]}

HERRINGTON, DA ^{[1
]}

WEBSTER, HK ^{[1
]}

CLYDE, DF ^{[1
]}

SZTEIN, MB ^{[1
]}

DAVIS, JR ^{[1
]}

BEIER, MS ^{[1
]}

EDELMAN, R ^{[1
]}

机构：

[1] UNIV MARYLAND,CTR VACCINE DEV,BALTIMORE,MD 21201

来源：

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE | 1992年 / 86卷 / 02期

关键词：

D O I：

10.1016/0035-9203(92)90539-O

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

To investigate the kinetics of monocyte/macrophage activation in falciparum malaria we determined urinary neopterin values serially in experimentally infected volunteers. Three subjects who had been immunized with irradiated sporozoites via mosquito bites served as controls. These individuals remained aparasitaemic, afebrile and without a rise in neopterin after challenge by infective mosquitoes. Four non-immune subjects developed Plasmodium falciparum parasitaemia, fever (3 of 4) and sharp rises in neopterin. Parasite densities reached 10-100 parasitized erythrocytes per mu-l before elevations in temperature or neopterin levels were detected. Onset of fever preceded the rise in neopterin excretion by one day. Prompt chemotherapy was associated with the clearance of parasites from the blood and the return of temperature and neopterin levels to normal.

引用

页码：134 / 136

页数：3

共 15 条

[1]

AULITZKY WE, 1988, CLIN NEPHROL, V29, P248

[2]

BROWN AE, 1990, CLIN EXP IMMUNOL, V82, P97, DOI 10.1111/j.1365-2249.1990.tb05410.x

[3]

BROWN AE, 1992, IN PRESS PARASITE IM

[4]

DAVIS JR, 1992, IN PRESS EXPT PARASI

[5]

DINARELLO CA, 1988, REV INFECT DIS, V10, P168

[6] INHIBITION OF DEVELOPMENT OF EXOERYTHROCYTIC FORMS OF MALARIA PARASITES BY GAMMA-INTERFERON [J].

FERREIRA, A ;

SCHOFIELD, L ;

ENEA, V ;

SCHELLEKENS, H ;

VANDERMEIDE, P ;

COLLINS, WE ;

NUSSENZWEIG, RS ;

NUSSENZWEIG, V .

SCIENCE, 1986, 232 (4752) :881-884

[7] DETERMINATION OF NEOPTERINE IN HUMAN-URINE BY REVERSED-PHASE HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY [J].

HAUSEN, A ;

FUCHS, D ;

KONIG, K ;

WACHTER, H .

JOURNAL OF CHROMATOGRAPHY, 1982, 227 (01) :61-70

[8]

HERRINGTON D, 1991, IN PRESS AM J TROPIC

[9]

HERRINGTON DA, 1988, TROP GEOGR MED, V40, P124

[10] SAFETY AND IMMUNOGENICITY IN MAN OF A SYNTHETIC PEPTIDE MALARIA VACCINE AGAINST PLASMODIUM-FALCIPARUM SPOROZOITES [J].

HERRINGTON, DA ;

CLYDE, DF ;

LOSONSKY, G ;

CORTESIA, M ;

MURPHY, JR ;

DAVIS, J ;

BAQAR, S ;

FELIX, AM ;

HEIMER, EP ;

GILLESSEN, D ;

NARDIN, E ;

NUSSENZWEIG, RS ;

NUSSENZWEIG, V ;

HOLLINGDALE, MR ;

LEVINE, MM .

NATURE, 1987, 328 (6127) :257-259

← 1 2 →