POSSIBLE ROLE OF NITRIC-OXIDE IN TRANSMITTING INFORMATION FROM VASODILATOR NERVE TO CEREBROARTERIAL MUSCLE

被引：194

作者：

TODA, N

OKAMURA, T

机构：

[1] Department of Pharmacology, Shiga University of Medical Sciences, Seta, Ohtsu

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1990年 / 170卷 / 01期

关键词：

D O I：

10.1016/0006-291X(90)91275-W

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Treatment with L-NG-monomethyl arginine (L-NMMA), an inhibitor of nitric oxide (NO) synthesis from L-arginine, suppressed the relaxant response of dog cerebral artery strips to transmural electrical stimulation and nicotine, as did oxyhemoglobin. The inhibition by L-NMMA was reversed or prevented by L-, but not D-, arginine. It is concluded that NO or an NO-related compound may play a crucial role in transmitting information from excited vasodilator nerves to cerebroarterial smooth muscle. © 1990.

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页码：308 / 313

页数：6

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