OXIDATIVE DAMAGE OF MITOCHONDRIA INDUCED BY FE(II)CITRATE OR T-BUTYL HYDROPEROXIDE IN THE PRESENCE OF CA2+ - EFFECT OF COENZYME-Q REDOX STATE

被引：59

作者：

CASTILHO, RF ^{[1
]}

KOWALTOWSKI, AJ ^{[1
]}

MEINICKE, AR ^{[1
]}

VERCESI, AE ^{[1
]}

机构：

[1] UNIV ESTADUAL CAMPINAS, INST BIOL, DEPT BIOQUIM, BR-13084100 CAMPINAS, SP, BRAZIL

来源：

FREE RADICAL BIOLOGY AND MEDICINE | 1995年 / 18卷 / 01期

基金：

巴西圣保罗研究基金会;

关键词：

RAT LIVER MITOCHONDRIA; COENZYME Q REDOX STATE; CALCIUM ION; REACTIVE OXYGEN SPECIES; LIPID PEROXIDATION; PROTEIN OXIDATION; FREE RADICALS;

D O I：

10.1016/0891-5849(94)00098-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The role of coenzyme Q on the process of mitochondrial membrane damage associated with oxidative stress was studied in a suspension of uncoupled mitochondria exposed to Ca2+ in the presence of Fe(II)citrate or t-butyl hydroperoxide. Reduction of coenzyme Q by succinate was shown to inhibit both inner membrane lipid peroxidation and permeabilization induced by Fe(II)citrate, In contrast, the inner membrane permeabilization induced by Ca2+ alone or Ca2+ plus t-butyl hydroperoxide was potentiated by the presence of succinate. These results support our previous proposition that the mitochondrial damage associated with oxidative stress generated by these prooxidants in the presence of Ca2+ is mediated by different mechanisms.

引用

页码：55 / 59

页数：5

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