EFFECT OF FLOW RATE ON DISTRIBUTION KINETICS OF A DRUG FROM PERFUSATE TO A PERFUSED ORGAN

被引：7

作者：

NAGASHIMA, R

LEVY, G

机构：

[1] Biopharmaceutics Laboratory, Department of Pharmaceutics, School of Pharmacy, State University of New York at Buffalo, Buffalo, New York

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1968年 / 57卷 / 11期

关键词：

Drug distribution—perfusate to rat liver; Flow rate; perfusate—drug‐distribution effect; Pharmacokinetics—flow rate‐drug distribution;

D O I：

10.1002/jps.2600571140

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A pharmacokinetic analysis of the distribution of a drug into a perfused organ or hypothetical compartment of the body yields mathematical expressions which may be useful for ascertaining if the distribution of a drug is rate limited by the flow of the perfusate, by the diffusion of the drug from the perfusate into the organ, or if it is a function of both of these processes. These expressions have been used to analyze the distribution of a drug from a perfusing fluid into the isolated perfused rat liver, and of several drugs from a hypothetical central compartment to a hypothetical peripheral compartment in man. Copyright © 1968 Wiley‐Liss, Inc., A Wiley Company

引用

页码：2000 / +

页数：1

共 11 条

[1]

Altman P.L., 1961, BLOOD OTHER BODY FLU, P1

[2] EFFECT OF PERFUSION RATE AND DISTRIBUTION FACTORS ON DRUG ELIMINATION KINETICS IN A PERFUSED ORGAN SYSTEM [J].

NAGASHIMA, R ;

LEVY, G .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1968, 57 (11) :1991-+

[3] COMPARATIVE PHARMACOKINETICS OF COUMARIN ANTICOAGULANTS .3. FACTORS AFFECTING DISTRIBUTION AND ELIMINATION OF BISHYDROXYCOUMARIN (BHC) IN ISOLATED LIVER PERFUSION STUDIES [J].

NAGASHIMA, R ;

LEVY, G ;

SARCIONE, EJ .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1968, 57 (11) :1881-+

[4]

NAGASHIMA R, UNPUBLISHED DATA

[5]

PAPPER EM, 1963, UPTAKE DISTRIBUTI ED, P123

[6] INTERTISSUE DIFFUSION EFFECT FOR INERT FAT-SOLUBLE GASES [J].

PERL, W ;

RACKOW, H ;

SALANITRE, E ;

WOLF, GL ;

EPSTEIN, RM .

JOURNAL OF APPLIED PHYSIOLOGY, 1965, 20 (04) :621-+

[7]

PRICE HL, 1963, UPTAKE DISTRIBUTION, P123

[8] SIMULTANEOUS UPTAKE OF N2O AND CYCLOPROPANE IN MAN AS A TEST OF COMPARTMENT MODEL [J].

RACKOW, H ;

SALANITRE, E ;

EPSTEIN, RM ;

WOLF, GL ;

PERL, W .

JOURNAL OF APPLIED PHYSIOLOGY, 1965, 20 (04) :611-+

[9]

RESCIGNO A, 1966, DRUG TRACER KINETICS, P84

[10] SHORTCOMINGS IN PHARMACOKINETIC ANALYSIS BY CONCEIVING BODY TO EXHIBIT PROPERTIES OF A SINGLE COMPARTMENT [J].

RIEGELMAN, S ;

LOO, JCK ;

ROWLAND, M .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1968, 57 (01) :117-+

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