ANALGESIA AFTER PERIPHERAL ADMINISTRATION OF ENKEPHALIN AND ENDORPHIN ANALOGS

被引：19

作者：

KASTIN, AJ ^{[1
]}

JEMISON, MT ^{[1
]}

COY, DH ^{[1
]}

机构：

[1] TULANE UNIV,SCH MED,NEW ORLEANS,LA 70146

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1979年 / 11卷 / 06期

关键词：

Analgesia; Binding sites; Endorphin; Enkephalin; Lipophilic; Met-enkephalin; β-Endorphin;

D O I：

10.1016/0091-3057(79)90268-5

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Several analogues of Met-enkephalin and β-endorphin were tested for their analgesic properties after systemic injection. The latencies of mice to flick their tails away from a source of heat revealed that analogues of the opiate peptides can cause analgesia when injected by this route. In particular, compounds specifically designed to be more lipophilic or to possess additional binding sites were shown to be potent analgesic agents after peripheral administration. © 1979.

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收藏

页码：713 / 716

页数：4

相关论文

共 12 条

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BRAIN RESEARCH BULLETIN, 1977, 2 (06) :479-484

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KASTIN, AJ ;

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