A 3D MODEL OF THE PERIPHERAL BENZODIAZEPINE RECEPTOR AND ITS IMPLICATION IN INTRA MITOCHONDRIAL CHOLESTEROL TRANSPORT

被引:92
作者
BERNASSAU, JM [1 ]
REVERSAT, JL [1 ]
FERRARA, P [1 ]
CAPUT, D [1 ]
LEFUR, G [1 ]
机构
[1] SANOFI ELF BIORECH,LABEGE,FRANCE
来源
JOURNAL OF MOLECULAR GRAPHICS | 1993年 / 11卷 / 04期
关键词
MOLECULAR DYNAMICS; BENZODIAZEPINE RECEPTOR; PROTEIN MODELING;
D O I
10.1016/0263-7855(93)80003-A
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
A three-dimensional (3D) model of the peripheral benzodiazepine receptor (PBR) has been built using molecular dynamics simulations. The transmembrane domain of the receptor has been modeled as five alpha-helices, which are not long enough to cross the entire bilayer membrane but correspond approximately to only one phospholipid layer. The receptor model has also been rested as a cholesterol carrier, and molecular dynamics simulations have shown that it could indeed accommodate a cholesterol molecule within the five helices. All three known PBR sequences have been modeled, non no significant difference has been found between them.
引用
收藏
页码:236 / 244
页数:9
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