TOXICITY OF CHEMICALLY GENERATED NITRIC-OXIDE TOWARDS PANCREATIC-ISLET CELLS CAN BE PREVENTED BY NICOTINAMIDE

被引：120

作者：

KALLMANN, B

BURKART, V

KRONCKE, KD

KOLBBACHOFEN, V

KOLB, H

机构：

[1] UNIV DUSSELDORF,DIABET RES INST,HENNEKAMP 65,W-4000 DUSSELDORF 1,GERMANY

[2] UNIV DUSSELDORF,DIV IMMUNOBIOL,W-4000 DUSSELDORF 1,GERMANY

来源：

LIFE SCIENCES | 1992年 / 51卷 / 09期

关键词：

D O I：

10.1016/0024-3205(92)90240-P

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Previous studies have indicated that nitric oxide is involved in the lysis of pancreatic islet cells by inflammatory macrophages. Here we show that the incubation of islet cells with chemical NO-donors leads to cell lysis in a concentration and time dependent way. Islet cell death could be prevented by nicotinamide and 3-aminobenzamide, which are known to inhibit ADP-ribosylation, while several scavengers of oxygen radicals, N-acetylcysteine, dihydrolipoic acid, dimethylthiourea and citiolone, provided no protection.

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页码：671 / 678

页数：8

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